Background. Primary hyperaldosteronism is a known cause for secondary hypertension. In addition to its effect on blood pressure,\naldosterone exhibits proinflammatory actions and plays a role in immunomodulation/development of autoimmunity. Recent\nresearches also suggest significant thyroid dysfunction among patients with hyperaldosteronism, but exact causal relationship is\nnot established. Autoimmune hyperthyroidism (Graves� disease) and primary hyperaldosteronism rarely coexist but underlying\nmechanisms associating the two are still unclear. Case Presentation. A 32-year-old Sri Lankan female was evaluated for new onset\nhypertension in associationwith hypokalemia. She also had features of hyperthyroidism together with high TSHreceptor antibodies\nsuggestive ofGraves� disease.On evaluation of persistent hypokalemia and hypertension, primary hyperaldosteronism due to rightsided\nadrenal adenoma was diagnosed. She was rendered euthyroid with antithyroid drugs followed by right-sided adrenalectomy.\nAntithyroid drugs were continued up to 12 months, after which the patient entered remission of Graves� disease. Conclusion.\nAutoimmune hyperthyroidism and primary hyperaldosteronism rarely coexist and this case report adds to the limited number\nof cases documented in the literature. Underlying mechanism associating the two is still unclear but possibilities of autoimmune\nmechanisms and autoantibodies warrant further evaluation and research.
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